Substance/Medication-Induced Depressive Disorder, as outlined in the DSM-5, occurs when depressive symptoms emerge during or shortly after the use, intoxication, or withdrawal of a substance or medication. Symptoms include persistent sadness, loss of interest or pleasure in activities (anhedonia), fatigue, changes in appetite and sleep patterns (insomnia or hypersomnia), feelings of worthlessness or excessive guilt, difficulty concentrating, psychomotor agitation or retardation, and recurrent thoughts of death or suicide. These depressive symptoms cannot be better explained by an underlying depressive disorder and must be linked directly to substance use or withdrawal. Common substances implicated include alcohol, opioids, sedatives, stimulants, and certain medications such as corticosteroids or hormonal treatments. Depressive symptoms induced by substances may be understood as a manifestation of underlying emotional pain and the fragmentation of the self. These individuals may use substances as a coping mechanism to manage unresolved emotional conflicts, stemming from early relational failures or trauma that compromised self-cohesion. In this view, the use of substances may temporarily numb or suppress emotional pain, but it also prevents the individual from achieving emotional integration or resolution of deep-seated feelings of emptiness, self-doubt, and disconnection. Self-psychological treatment, therefore, would aim to provide an empathic, attuned therapeutic relationship where the individual can explore the emotional roots of their substance use and depressive symptoms, while working through feelings of misattunement, isolation, or unworthiness. The therapy focuses on restoring self-cohesion and helping the individual build healthier emotional responses that no longer rely on substances as a form of emotional regulation.